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Genome-wide mapping of H3K4me3 and H3K27ac in monocytes from SARS-CoV-2 convalescent patients.

ABSTRACT: Epigenetic alterations of monocytes from COVID-19 convalescent individuals and healthy controls have been analyzed by mapping trimethylated H3K4 (H3K4me3) and acetylated H3K27 (H3K27ac) genome-wide using CUT&RUN (Skene & Henikoff, 2017). Epigenetic reprogramming of myeloid cells represents a hallmark of trained innate immunity (Netea, Joosten et al., 2016). In general, active enhancers are marked by H3K27ac and transcription start sites are marked by H3K4me3 and H3K27ac (Kimura, 2013). A global analysis of histone modifications associated with transcription start sites (TSS) revealed a difference in the overall coverage of specific loci in SC-conv versus SC-naïve cells with SC-conv samples showing lower occupancy overall

ORGANISM(S): Homo sapiens

PROVIDER: GSE173568 | GEO | 2021/06/07

REPOSITORIES: GEO

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