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Expression profiling of 143B-shCtrl and 143B-shIRX1 stable osteosarcoma cell lines

ABSTRACT: Pulmonary metastasis is the main cause of medical failure and death of osteosarcoma patients. Our recent study identified IRX1 as a potential metastasis-driving gene in osteosarcoma. Studies showed that IRX1 can promote the migration, invasion and anoikis resistance of osteosarcoma cells. We generated 143B stable IRX1 knockdown and control cell lines, and found that IRX1 knockdown can inhibit the pulmonary metastasis of 143B cells in orthotopic mouse osteosarcoma model. Expression microarrays are performed in143B-shCtrl and 143B-shIRX1 cells to study the mechanism of IRX1 on promoting metastasis of osteosarcoma

ORGANISM(S): Homo sapiens

SUBMITTER: Jinchang Lu 

PROVIDER: E-GEOD-55958 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling.

Lu Jinchang J   Song Guohui G   Tang Qinglian Q   Zou Changye C   Han Feng F   Zhao Zhiqiang Z   Yong Bicheng B   Yin Junqiang J   Xu Huaiyuan H   Xie Xianbiao X   Kang Tiebang T   Lam YingLee Y   Yang Huiling H   Shen Jingnan J   Wang Jin J  

The Journal of clinical investigation 20150330 5

Osteosarcoma is a common malignant bone tumor with a propensity to metastasize to the lungs. Epigenetic abnormalities have been demonstrated to underlie osteosarcoma development; however, the epigenetic mechanisms that are involved in metastasis are not yet clear. Here, we analyzed 2 syngeneic primary human osteosarcoma cell lines that exhibit disparate metastatic potential for differences in epigenetic modifications and expression. Using methylated DNA immunoprecipitation (MeDIP) and microarray  ...[more]

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