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MicroRNA expression in rat soleus muscle during atrophy induced by hindlimb suspension

ABSTRACT: The objective of the study was to identify microRNAs expressed in the rat soleus muscle and determine if their expression was changed in response to hindlimb suspension.

ORGANISM(S): synthetic construct Rattus norvegicus

PROVIDER: GSE17776 | GEO | 2009/08/25

SECONDARY ACCESSION(S): PRJNA118283

REPOSITORIES: GEO

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MicroRNA expression in rat soleus muscle during atrophy induced by hindlimb suspension

Project description:The objective of the study was to identify microRNAs expressed in the rat soleus muscle and determine if their expression was changed in response to hindlimb suspension. The microRNA expression profile (Sanger miRBase 9.0) of the rat soleus muscle was determined in the following three groups: control (C), hindlimb suspended for 2 days (HS-2) or 7 days (HS-7). Three replicates were performed for each group.

2009-08-25 | E-GEOD-17776 | biostudies-arrayexpress

Hindlimb suspension and reloading study

Project description:Analysis of effect of hindlimb suspension and reloading on C57Bl/6 mouse soleus muscle. Experimental groups examined: -Control mice, 14 days -Hindlimb suspension for 7 days -Hindlimb suspension for 7 days, and subsequent reloading for 1 day -Hindlimb suspension for 7 days, and subsequent reloading for 7 days Keywords: other

2004-09-30 | GSE1293 | GEO

Hindlimb suspension and reloading study

2010-06-05 | E-GEOD-1293 | biostudies-arrayexpress

Effect of electroacupuncture on the skeletal muscle atrophy induced by hindlimb suspension in mice

Project description:The effect of electroacupuncture on the transcriptional profile of the skeletal muscle atrophy induced by hindlimb suspension were examined. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated and down-regulated genes during this process.

2021-06-27 | GSE38874 | GEO

Hindlimb suspension

Project description:Hindlimb suspended for 7 days Keywords: repeat sample

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ALCAR supplementation to unloaded soleus muscle

Project description:The effect of acetyl-L-carnitine (ALCAR) supplementation to hindlimb suspended rats has been analyzed in order to test whether this would promote the differentiation towards an oxidative phenotype of muscle fibers in soleus muscle and prevent the transformation of this slow tonic muscle towards a glycolytic, low-oxidative phenotype due to unloading condition. 3 month-old rats were daily supplemented with ALCAR concomitantly with hindlimb suspension. Validated microarray analysis for a broad range of muscle-relevant processes delineated an ALCAR-induced adjustment of the expression profile. In particular, transcript elevations of factors underlying oxidative metabolism in mitochondria and protein turnover by ribosomal and proteasomal components as well as an adaptation of voltage-gated ion channel expression were identified as an ALCAR response in soleus muscle. Keywords: ALCAR effect

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Balanced Diet-Fed Fat-1 Transgenic Mice Exhibit Lower Hindlimb Suspension-Induced Soleus Muscle Atrophy.

Project description:The consequences of two-week hindlimb suspension (HS) on skeletal muscle atrophy were investigated in balanced diet-fed Fat-1 transgenic and C57BL/6 wild-type mice. Body composition and gastrocnemius fatty acid composition were measured. Skeletal muscle force, cross-sectional area (CSA), and signaling pathways associated with protein synthesis (protein kinase B, Akt; ribosomal protein S6, S6, eukaryotic translation initiation factor 4E-binding protein 1, 4EBP1; glycogen synthase kinase3-beta, GSK3-beta; and extracellular-signal-regulated kinases 1/2, ERK 1/2) and protein degradation (atrophy gene-1/muscle atrophy F-box, atrogin-1/MAFbx and muscle RING finger 1, MuRF1) were evaluated in the soleus muscle. HS decreased soleus muscle wet and dry weights (by 43% and 26%, respectively), muscle isotonic and tetanic force (by 29% and 18%, respectively), CSA of the soleus muscle (by 36%), and soleus muscle fibers (by 45%). Fat-1 transgenic mice had a decrease in the ω-6/ω-3 polyunsaturated fatty acids (PUFAs) ratio as compared with C57BL/6 wild-type mice (56%, p < 0.001). Fat-1 mice had lower soleus muscle dry mass loss (by 10%) and preserved absolute isotonic force (by 17%) and CSA of the soleus muscle (by 28%) after HS as compared with C57BL/6 wild-type mice. p-GSK3B/GSK3B ratio was increased (by 70%) and MuRF-1 content decreased (by 50%) in the soleus muscle of Fat-1 mice after HS. Balanced diet-fed Fat-1 mice are able to preserve in part the soleus muscle mass, absolute isotonic force and CSA of the soleus muscle in a disuse condition.

| S-EPMC5691716 | biostudies-literature

Transcription profiling of mouse extraocular and hindlimb muscle to determine gene expression changes in extraocular and hindlimb (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal day 56

Project description:Determination of gene expression changes in extraocular and hindlimb (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal day 56. 5 independent replicates/muscle group/strain.

2007-10-09 | E-GEOD-1472 | biostudies-arrayexpress

Transcriptome of reloaded soleus muscle of 129/SV mice

Project description:1 year-old male 129/SV mice. Animals were acclimatized to housing in single cages for one week followed by 7 days of hindlimb suspension and one day of reloading. Soleus muscle was harvested, total RNA isolated and subjected to transcript profiling with custom microarrays with custom-designed ATLASTM cDNA nylon filter as described (Dapp, C., Schmutz, S., Hoppeler, H. & Fluck, M. (2004) Physiol Genomics 20, 97-107). Keywords: transcriptome

2008-08-08 | GSE8549 | GEO

miRNAs expression of soleus response to simulated microgravity

Project description:Identification of gravisensitive miRNAs expression in rat soleus muscle exposed to 7 and 14 days of Hindlimb suspension (HS) simulated microgravity. Microgravity causes muscle atrophy possibly due to muscle wasting overtake regeneration. Results provide insight into the molecular mechanisms regulating muscle atrophy. The expression of 23 out of 174 miRNAs was found to change at least 2-fold of 7 and/or 14 days of TS. By using real-time PCR assays, we verified the microarray data using some of the expected genes.

2013-11-05 | GSE52055 | GEO

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