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Microbiome-specific T follicular helper cells drive tertiary lympohid structures and anti-tumor immunity against colorectal cancer

ABSTRACT: Advanced or metastatic colorectal cancer is largely refractory to current therapeutic regimens and correspondingly has poor prognosis. The microbiota plays an important role in controlling the host immune response, with unique bacterial species able to activate and differenation specific subpopulations of T cells in the colon. Using an orthotopic carcinogen-induced murine model of colorectal cancer, we found that pertubation of the microbiome with Helicobacter hepaticus led to increased antitumor immunity and disease control. Single-cell RNAseq analysis was used to interrogate the tumor microenvironment and lamina propria in Helicobacter hepaticus colonized and control mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE178485 | GEO | 2021/12/01

REPOSITORIES: GEO

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