Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transgenic MYC OFF timecourse in murine MYC-dependent cell line

ABSTRACT: In this experiment we determine MYC-dependent changes in a MYC OFF time-course. Using the established 4188 cell line derived from the Eμ-tTA/Tet-O-MYC primary model of T-ALL, we performed RNA-seq at 0 (MYC ON), and 4, 8, 12, 24, and 48 hours after addition of 20ng/µl doxycycline (MYC OFF)

ORGANISM(S): Mus musculus

PROVIDER: GSE178580 | GEO | 2021/07/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene Expression Analysis of Transgenic Myc-Driven Liver Tumor Formation and Regression

Project description:Gene expression changes were examined in transgenic MYC-driven liver cancers at different time points as tumors formed and upon early regression. Time points evaluated include: Control (non-tumor bearing), Pre-tumor (mice were removed from doxyclycine in their diet to induce MYC oncogene expression for 4-5 weeks), Tumor (tumor nodules from mice that had been off of doxycycline for 8-9 weeks) and Early tumor regression (tumor-bearing mice were placed back on doxycycline for 72 hrs to inhibit MYC oncogene expresion). MYC-Driven Mouse Tumor Models are described in Schahaf, et al., Nature, 2004 and Goga, et al., Nature Medicine, 2007. 11 Total Samples: 3 Control, 4 Pre-Tumor, 4 Tumor, 4 Early Tumor Regression. Control = LAP-tTA transgenic mice. Others = TRE-MYC x LAP-tTA double transgenic mice (doxy off).

2011-07-06 | E-GEOD-28198 | biostudies-arrayexpress

rDNA chromatin interactions in the MYC-driven Eμ-Myc transgenic mouse model of B-cell lymphoma [4C-seq]

Project description:Long-range interactions of ribososomal DNA (rDNA) identified by 4C-seq in mouse wildtype, premalignant and malignant Eμ-Myc cells and tissue culture adapated Eμ-Myc-shUbtf and Eμ-Myc-LMP (empty vector) cells.

2019-02-06 | GSE70221 | GEO

Gene expression profile of c-MYC driven mouse liver tumours, compared with Normal livers from control mice

Project description:Liver tumours are induced by overexpresion of human c-MYC (LAP-tTA/tet-o-MYC) Using Affymetrix microarrays we compared gene expression of both tissues

2020-03-27 | GSE129013 | GEO

Gene expression in murine T-ALL following titrated MYC inactivation

Project description:To understand changes to gene expression in murine T-ALL following MYC inactivation, T-ALL cells were isolated from EμSRα-tTA/tet-O-MYC/FVB/N mice and treated with varying concentrations of doxycyline for 48 hours to place cells in the MYC on, MYC intermediate, or MYC off state.

2023-02-28 | GSE222937 | GEO

Time course of gene expression in murine T-ALL following MYC inactivation

Project description:To understand changes to gene expression over time in murine T-ALL following MYC inactivation, T-ALL cells were isolated from EμSRα-tTA/tet-O-MYC/FVB/N mice and treated with doxycyline to turn MYC off for varying amounts of time before assessing gene expression.

2023-02-28 | GSE222938 | GEO

MYC-driven mouse HCC proteomics

Project description:To identify proteomic signatures associated with hepatocellular carcinoma driven by MYC overexpression, proteomics was performed on the LAP-tTA/tetO-MYC mouse conditional liver cancer model. Upon MYC activation, mice form liver cancer. Differential proteomics was performed in "MYC on" (MYC-HCC) mouse liver tumors versus mouse control normal liver tissue (where MYC was not overexpressed to drive tumorigenesis -- "MYC off").

2022-10-12 | PXD031478 | Pride

rDNA chromatin interactions in the MYC-driven Eμ-Myc transgenic mouse model of B-cell lymphoma [RNA-seq]

Project description:Analysis of gene expression by RNA-seq in mouse wildtype, premalignant and malignant Eμ-Myc cells.

2019-02-06 | GSE70224 | GEO

MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

Project description:We delineate the immunobiology during MYC oncogene-driven lymphomagenesis by RNA sequencing analysis followed by CIBERSORT of bulk splenic samples from healthy and SRa-tTA/tet-O-MYC mice before and after MYC inactivation. The data set also delineates global changes in signaling molecules in healthy spleens (controls) and lymphomagenic spleens in MYC ON and MYC OFF states.

2020-04-20 | GSE106078 | GEO

rDNA chromatin interactions in the MYC-driven Eμ-Myc transgenic mouse model of B-cell lymphoma [ChIP-seq]

Project description:Analysis of PolI and H3K27me3 binding patterns by ChIP-seq in mouse wildtype, premalignant and malignant Eμ-Myc cells.

2019-08-01 | GSE70225 | GEO

rDNA chromatin interactions in the MYC-driven Eμ-Myc transgenic mouse model of B-cell lymphoma [ChIP-seq UTF]

Project description:Analysis of Upstream Binding Transcription Factor (UBTF) binding patterns by ChIP-seq in mouse wildtype, premalignant and malignant Eμ-Myc cells.

2019-02-06 | GSE123324 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data