Dataset Information
MYC-driven mouse HCC proteomics
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: 
Delaney Sullivan
LAB HEAD: Sharon Pitteri
PROVIDER: PXD031478 | Pride | 2022-10-12
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Key.xlsx | Xlsx | |||
| MYC_1_062918_01.raw | Raw | |||
| MYC_1_062918_01.raw_20180702_Byonic_database.xlsx | Xlsx | |||
| MYC_1_062918_02.raw | Raw | |||
| MYC_1_062918_02.raw_20180702_Byonic_database.xlsx | Xlsx |
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Publications
MYC oncogene elicits tumorigenesis associated with embryonic, ribosomal biogenesis, and tissue-lineage dedifferentiation gene expression changes.
Oncogene 20221007 45
MYC is a transcription factor frequently overexpressed in cancer. To determine how MYC drives the neoplastic phenotype, we performed transcriptomic analysis using a panel of MYC-driven autochthonous transgenic mouse models. We found that MYC elicited gene expression changes mostly in a tissue- and lineage-specific manner across B-cell lymphoma, T-cell acute lymphoblastic lymphoma, hepatocellular carcinoma, renal cell carcinoma, and lung adenocarcinoma. However, despite these gene expression chan ...[more]
