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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [ChIP-seq]

ABSTRACT: Purpose: Decipher the role of REST in pancreas organogenesis and endocrine differentiation (REST ChIPseq-samples E13.5 and E18.5 pancreas)

ORGANISM(S): Mus musculus

PROVIDER: GSE179118 | GEO | 2021/06/30

REPOSITORIES: GEO

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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [RNA-seq]

Project description:Purpose: Decipher the role of REST in pancreas organogenesis and endocrine differentiation (REST RNAseq-samples E18.5 pancreas)

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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis.

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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [ChIP-seq]

Project description:The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [ChIP-seq]

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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis.

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-30 | GSE179120 | GEO

REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.

Project description:Multiple transcription factors have been shown to promote pancreatic β-cell differentiation, yet much less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST could be a suppressor of endocrinogenesis in the embryonic pancreas. However, pancreatic Rest knockout mice failed to show abnormal numbers of endocrine cells, suggesting that REST is not a major regulator of endocrine differentiation. Using a different conditional allele that enables profound REST inactivation, we observed a marked increase in pancreatic endocrine cell formation. REST inhibition also promoted endocrinogenesis in zebrafish and mouse early postnatal ducts and induced β-cell-specific genes in human adult duct-derived organoids. We also defined genomic sites that are bound and repressed by REST in the embryonic pancreas. Our findings show that REST-dependent inhibition ensures a balanced production of endocrine cells from embryonic pancreatic progenitors.

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REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells

Project description:Genome-wide analysis of REST and Polycomb binding in Rest-/- and Eed-/- mouse embryonic stem (mES) cells showed that Rest was required for PRC1 recruitment to a subset of Polycomb regulated neuronal genes. Furthermore, we found that PRC1 can be recruited to Rest binding sites independently of CpG islands and the H3K27Me3 mark., and that PRC2 was frequently increased around Rest binding sites located in CpG-rich regions in the Rest2/2 mES cells. Published here: PLoS Genet 8(3): e1002494. doi:10.1371/journal.pgen.1002494

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REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells

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The transcriptome of pancreatic epithelial cells at different stages during fetal organogenesis [RNA-seq]

Project description:To investigate the transcriptome at different stages of pancreatic organogenesis, we sorted by flow cytometry the pancreatic epithelial from fetal murine pancreas.

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Polycomb Repressor Complex2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype

Project description:These experiments were designed to test the hypothesis that REST and Polycomb Repressor Complex 2 function cooperatively in undifferentiated ESCs. Our results show that H3K27me3-enriched genes show no de-repression in REST-/- ESCs, while REST target genes show significant de-repression.

2014-09-30 | GSE59442 | GEO

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