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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis.

ABSTRACT: The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis.

PROVIDER: PRJNA742255 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14936543.fastq.gz	Fastqsanger.gz
	SRR14936544.fastq.gz	Fastqsanger.gz
	SRR14936545.fastq.gz	Fastqsanger.gz
	SRR14936546.fastq.gz	Fastqsanger.gz
	SRR14936547.fastq.gz	Fastqsanger.gz

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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [RNA-seq]

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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [ChIP-seq]

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Project description:The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [ChIP-seq]

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The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis [RNA-seq]

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REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.

Project description:Multiple transcription factors have been shown to promote pancreatic β-cell differentiation, yet much less is known about negative regulators. Earlier epigenomic studies suggested that the transcriptional repressor REST could be a suppressor of endocrinogenesis in the embryonic pancreas. However, pancreatic Rest knockout mice failed to show abnormal numbers of endocrine cells, suggesting that REST is not a major regulator of endocrine differentiation. Using a different conditional allele that enables profound REST inactivation, we observed a marked increase in pancreatic endocrine cell formation. REST inhibition also promoted endocrinogenesis in zebrafish and mouse early postnatal ducts and induced β-cell-specific genes in human adult duct-derived organoids. We also defined genomic sites that are bound and repressed by REST in the embryonic pancreas. Our findings show that REST-dependent inhibition ensures a balanced production of endocrine cells from embryonic pancreatic progenitors.

| S-EPMC8415321 | biostudies-literature

The transcriptional repressor REST is a major suppressor of endocrine differentiation during pancreas organogenesis.

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-30 | GSE179120 | GEO

Transcription profiling of cells from four developmental stages of human endocrine pancreas to define genetic pathways that regulate endocrine pancreatic development

Project description:To define genetic pathways that regulate development of the endocrine pancreas, we generated transcriptional profiles of enriched cells isolated from four biologically significant stages of endocrine pancreas development: endoderm before pancreas specification, early pancreatic progenitor cells, endocrine progenitor cells and adult islets of Langerhans. These analyses implicate new signaling pathways in endocrine pancreas development, and identified sets of known and novel genes that are temporally regulated, as well as genes that spatially define developing endocrine cells from their neighbors. The differential expression of several genes from each time point was verified by RT-PCR and in situ hybridization. Moreover, we present preliminary functional evidence suggesting that one transcription factor encoding gene (Myt1), which was identified in our screen, is expressed in endocrine progenitors and may regulate alpha, beta and delta cell development. In addition to identifying new genes that regulate endocrine cell fate, this global gene expression analysis has uncovered informative biological trends that occur during endocrine differentiation.

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