Transcriptional dynamics in HUVECs and fetal endothelial progenitor cells during establishment of innate immune memory

ABSTRACT: Innate immune memory (also known as Trained immunity) is a phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to certain microbial components, altering their responses to future exposures. Recent data show that this phenomenon occurs in endothelial cells. In this study we mapped the transcriptional changes that occur in two different types of fetal endothelial cells in response to an initial viral ligand, followed by a secondary bacterial exposure.

ORGANISM(S): Homo sapiens

PROVIDER: GSE180881 | GEO | 2021/11/06

REPOSITORIES: GEO