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Transcriptional remodeling of primary human monocytes exposed to itaconate and its derivatives in the context of trained immunity

ABSTRACT: Trained immunity is a phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to certain microbial components, altering their responses to future exposures. This study profiled the transcriptome of human monocytes and in vitro differentiated macrophages, exposed to a combination of LPS, BG, DMI, or Itaconate.

ORGANISM(S): Homo sapiens

PROVIDER: GSE212282 | GEO | 2023/06/26

REPOSITORIES: GEO

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