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Single-cell RNA-seq of control and Sendai virus-infected mouse lungs [1wk/7wk timepoint]

ABSTRACT: The Sendai virus infection model induces global changes involving multiple lung cell types. At 1 week post-infection, there is acute damage to the lung. At 2 weeks post-infection, when the virus had been largely cleared and the lung is undergoing repair, proliferation of endothelial cells and alveolar type 2 (AT2) cells is observed, as well as aberrant appearance Trp63/Sox2-expressing basal-like cells reminiscent of pods or lineage-negative epithelial progenitors observed upon severe H1N1 virus infection. At 7 weeks post-infection, the lung has been largely repaired, though the Trp63/Sox2-expressing basal-like cells remain.

ORGANISM(S): Mus musculus

PROVIDER: GSE180950 | GEO | 2021/07/30

REPOSITORIES: GEO

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Single-cell RNA-seq of control and Sendai virus-infected mouse lungs [2wk timpoint]

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