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Transcription profiling of mouse C57BL/6J strain infected with Sendai virus vs. UV irradiated virus to investigate virus-induced airway disease

ABSTRACT: Analysis of gene expression in lungs of C57BL/6J mice that develop chronic airway disease phenotypes after a single Sendai virus infection, compared with mice treated with UV-inactivated virus. Experiment Overall Design: Whole lung RNA was analyzed from 3 mice per condition per time point for days 21 and 49 post infection, Sendai virus versus UV-inactivated virus, C57BL/6J mouse strain.

ORGANISM(S): Mus musculus

SUBMITTER: Anand Champak Patel

PROVIDER: E-GEOD-10964 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.

Kim Edy Y EY Battaile John T JT Patel Anand C AC You Yingjian Y Agapov Eugene E Grayson Mitchell H MH Benoit Loralyn A LA Byers Derek E DE Alevy Yael Y Tucker Jennifer J Swanson Suzanne S Tidwell Rose R Tyner Jeffrey W JW Morton Jeffrey D JD Castro Mario M Polineni Deepika D Patterson G Alexander GA Schwendener Reto A RA Allard John D JD Peltz Gary G Holtzman Michael J MJ

Nature medicine 20080518 6

To understand the pathogenesis of chronic inflammatory disease, we analyzed an experimental mouse model of chronic lung disease with pathology that resembles asthma and chronic obstructive pulmonary disease (COPD) in humans. In this model, chronic lung disease develops after an infection with a common type of respiratory virus is cleared to only trace levels of noninfectious virus. Chronic inflammatory disease is generally thought to depend on an altered adaptive immune response. However, here w ...[more]

PMID: 18488036

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Virus-Induced Airway Disease in Mice (C57BL/6J, d49)

Project description:Analysis of gene expression in lungs of C57BL/6J mice that develop chronic airway disease phenotypes after a single Sendai virus infection, compared with mice treated with UV-inactivated virus. Keywords: disease state analysis Whole lung RNA was analyzed from 3 mice per condition per time point 49 days post infection, Sendai virus versus UV-inactivated virus, C57BL/6J mouse strain.

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