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The prostate cancer androgen receptor cistrome in African American men differs from White men and associates with upregulation of lipid metabolism [EA]

ABSTRACT: We use androgen receptor chromatin immunoprecipitation (AR ChIP) on frozen prostate adenocarcinoma samples and normal prostate counterparts in men of European ancestry as well as men of African (AA) ancestry and derive a model whereby increased androgen signaling drives higher levels of lipogenesis in AA prostate tumors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE181441 | GEO | 2022/06/08

REPOSITORIES: GEO

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The prostate cancer androgen receptor cistrome in African American men differs from White men and associates with upregulation of lipid metabolism [AA]

Project description:We use androgen receptor chromatin immunoprecipitation (AR ChIP) on frozen prostate adenocarcinoma samples and normal prostate counterparts in men of European ancestry as well as men of African (AA) ancestry and derive a model whereby increased androgen signaling drives higher levels of lipogenesis in AA prostate tumors.

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Expression data from prostate cancer epithelial cells from African American and European American men

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The prostate cancer androgen receptor cistrome in African American men differs from White men and associates with upregulation of lipid metabolism [EA]

Project description:The prostate cancer androgen receptor cistrome in African American men differs from White men and associates with upregulation of lipid metabolism [EA]

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Project description:In this study, we used a precision medicine approach to examine molecular profiles and cellular stress responses in an important segment of AA and EA men: men undergoing prostate biopsy. The primary goal in the present study was to demonstrate the ability to assess the prostate transcriptome with a single biopsy core while further examining molecular differences in gene expression patterns relevant to prostate cancer disparities between AA and EA men in a new patient cohort presenting with early stage prostate cancer. To further this objective, we undertook a series of genome wide expression profiling experiments using high throughput RNA sequencing (RNA-Seq). RNA was purified from core biopsy prostate tissue specimens obtained from deidentified subjects enrolled in the study. Transcriptional profiles of each of the deidentified patient’s tissue samples were generated and systems level analyses were performed. The results of these analyses were compared across racial groups.

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