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The prostate cancer androgen receptor cistrome in African American men differs from White men and associates with upregulation of lipid metabolism [AA]

ABSTRACT: The prostate cancer androgen receptor cistrome in African American men differs from White men and associates with upregulation of lipid metabolism [AA]

PROVIDER: PRJNA752082 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR15341854_1.fastq.gz	Fastqsanger.gz
	SRR15341854_2.fastq.gz	Fastqsanger.gz
	SRR15341855_1.fastq.gz	Fastqsanger.gz
	SRR15341855_2.fastq.gz	Fastqsanger.gz
	SRR15341856_1.fastq.gz	Fastqsanger.gz

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The prostate cancer androgen receptor cistrome in African American men differs from White men and associates with upregulation of lipid metabolism [AA]

Project description:We use androgen receptor chromatin immunoprecipitation (AR ChIP) on frozen prostate adenocarcinoma samples and normal prostate counterparts in men of European ancestry as well as men of African (AA) ancestry and derive a model whereby increased androgen signaling drives higher levels of lipogenesis in AA prostate tumors.

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The prostate cancer androgen receptor cistrome in African American men differs from White men and associates with upregulation of lipid metabolism [EA]

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Project description:The prostate cancer androgen receptor cistrome in African American men differs from White men and associates with upregulation of lipid metabolism [EA]

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Project description:African-American (AA) men experience increased risk of developing prostate cancers as well as increased mortality following treatment as compared to European-American (EA) men. The aim of our study was to identify biological factors with potential to predispose AA men to prostate tumor progression and metastasis. High-throughput microarrays were used to investigate differences in global gene expression comparing the two groups. Experiment Overall Design: To identify cancer-specific gene expression patterns in AA men, we established primary prostate cancer epithelial cells from 14 AA and 13 EA men. Cells were cultured for RNA extraction and hybridization on Affymetrix microarrays.

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Project description:There are many treatment options available for men with metastatic castration-resistant prostate cancer (mCRPC). Yet, biomarkers predictive of differential response to treatment are currently available. A recent translational study suggested that SLCO2B1 genotype could predict response to abiraterone acetate (AA) for men with advanced prostate cancer. Here, we investigate whether germline variants in SLCO2B1 are predictive of response to first-line AA in men with new mCRPC. Clinical data and samples were analyzed from a prospective prostate cancer registry at the University of Utah. Genotyping was performed using the Illumina OmniExpress genotyping platform. Primary endpoint was progression-free survival (PFS) on first-line AA in men with mCRPC. We performed a pre-speciﬁed multivariate Cox regression analysis to assess the independent predictive value of rs12422149 and rs1789693 on PFS on AA. Of 401 men with advanced prostate cancer genotyped, 323 were homozygous wild type for rs12422149 (80.5%), 74 were heterozygous (18.5%), and 4 were homozygous variant (1.0%). In a multivariate analysis of 79 men treated with first-line AA for mCRPC, men heterozygous for rs12422149 had significantly improved median PFS compared to the homozygous wild-type group (8.9 months vs. 6.3 months, HR 0.46, 95% CI 0.23-0.94, p=0.03). No significant difference in median PFS was seen by rs1789693 genotype. In this first clinical validation of translational data reported by Mostaghel and colleagues, germline variant alleles in rs12422149 of SLCO2B1 are common and predict improved response to first-line AA In men with mCRPC.

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A PRECISION MEDICINE APPROACH TO INTERROGATE GENE EXPRESSION PATTERNS IN AFRICAN MEN PRESENTING WITH EARLY STAGE PROSTATE CANCER.

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Macrophages Solvent, AA, LPS, AA+LPS

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MDMs Solvent, AA, IL6, AA+IL6

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