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Role of Setd2 in regulatory T cells [H3K36me3 ChIP-seq]

ABSTRACT: ChIP-sequencing for H3K36me3 analysis was performed on Tregs purified from the spleen and large intestine of naïve mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE182340 | GEO | 2022/10/14

REPOSITORIES: GEO

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Role of Setd2 in regulatory T cells

Project description:This SuperSeries is composed of the SubSeries listed below. To determine the molecular regulation of Tregs by Setd2, Spleen or large intestine Tregs (CD3+CD4+Foxp3-YFP+) were purified from littermate Foxp3Cre-YFPSetd2f/+ and Foxp3Cre-YFPSetd2f/f mice. Setd2-deficient and control Tregs were subjected to RNA-seq, RNA Polymerase II CUT&Tag or H3K27ac CUT&Tag analyses.

2022-10-14 | GSE182845 | GEO

Role of Setd2 in regulatory T cells [H3K27ac CUT&Tag]

Project description:To determine the molecular regulation of Tregs by Setd2, large intestine Tregs (CD3+CD4+Foxp3-YFP+) from Setd2-deficient and control Tregs were subjected to H3K27ac CUT&Tag analysis.

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Role of Setd2 in regulatory T cells [Pol II CUT&Tag]

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Role of Setd2 in regulatory T cells [H3K36me3 ChIP-seq]

Project description:Role of Setd2 in regulatory T cells [H3K36me3 ChIP-seq]

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Role of Setd2 in regulatory T cells [RNAseqTreg]

Project description:To determine the mechanism of regulation of Tregs by Setd2, LI Tregs (CD3+CD4+Foxp3-YFP+) from Setd2-deficient and control Tregs were subjected to RNA-seq analysis.

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Role of Adenosine 2A Receptors (A2AR) on regulatory T cells (Tregs)

Project description:The adenosine 2A receptor (A2AR) is expressed on regulatory T cells (Tregs), but the functional significance is currently unknown. We compared the gene expression between wild-type (WT) and A2AR knockout (KO) Tregs and between WT Tregs treated with vehicle or a selective A2AR agonist. FACS-sorted GFP positive Tregs from WT or A2AR KO FoxP3GFP mouse spleen and lymph nodes were incubated 18 hr with vehicle (DMSO), a separate set of WT Tregs were incubated with the selective A2AR agonist ATL1222 10 nM (Dogwood Pharmaceuticals, Inc.) for 18 hr prior to RNA isolation.

2012-05-31 | E-GEOD-34006 | biostudies-arrayexpress

Role of Setd2 on regulatory T cells [RNA-seq SP Treg]

Project description:To determine the mechanism of regulation of Tregs by Setd2, SPTregs (CD3+CD4+Foxp3-YFP+) from Setd2-deficient and control Tregs were subjected to RNA-seq analysis.

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Microarray expression analysis depicting MHCII-dependent features of FOXP3-expressing CD4 T regulatory cells

Project description:Analysis comparing K14 and MCHII+/- Tregs. The hypothesis was that the lack of MHCII+/- in the spleen and intestine would result in a large shift in K14 Treg gene expression away from an activated and effector phenotype. Results demonstrate how a lack of MHCII-antigen presentation in the small intestine, where Tregs exhibit an effector penotype, does not greatly reduce effector features of T regulatory cells in K14 mice.

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TNFRSF4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells

Project description:Purpose: The goal of this study was to compare transcriptome profile of FACS-purified bone marrow (BM) Tregs isolated from CML or naive mice. Methods: Transcriptomic profiles of BM Tregs from CML or naïve mice were assessed in biological replicates using Illumina NextSeq 500. Results: We mapped around 30 million sequence reads per sample to the mouse genome (GRCm38 - mm10) and identified expressed transcripts in FACS-purified BM Tregs isolated from CML or naive mice. RNA-seq data confirmed stable expression of known housekeeping genes. Differentially expressed genes between Tregs derived from the BM of CML and naïve mice were identified. Conclusions: Our study represents the first detailed RNA-seq analysis of FACS-purified BM Tregs isolated from CML or naive mice. Our results show that Tregs derived from the BM of CML mice have an increased metabolic activity, cell cycle activity and immunosuppressive capacity.

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Setd2 reprograns lipid metabolism for the resolution of inflammation via H3K36me3 modification

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