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4C-seq analyses of the 3’Igh locus during B cell development


ABSTRACT: We report the application of 4C-seq for analysis of the 3’ end of he Igh locus during B cell development. We generated genome-wide 4C maps for BM derived Rag2-/- pro-B cells, resting splenic B cells, LPS+IL4 activated B cells and ConA stimulated splenic T cells using two viewpoints, Em and hs4 located in 3’Ea. We find that long range interactions are present only on B lineage cells reflecting enhancer activation status.

ORGANISM(S): Mus musculus

PROVIDER: GSE183006 | GEO | 2021/11/23

REPOSITORIES: GEO

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