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Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [ATAC-seq]

ABSTRACT: The study examined transcriptional memory after dFOXO induction in fat body and gut of young adult female fruit flies.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE183540 | GEO | 2022/10/06

REPOSITORIES: GEO

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Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [RNA-seq]

Project description:The study examined transcriptional memory after dFOXO induction in fat body and gut of young adult female fruit flies.

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Transcriptional memory of dFOXO activity in early adulthood delays late life mortality.

Project description:This SuperSeries is composed of the SubSeries listed below.

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Transcriptional memory of dFOXO activity in early adulthood delays late life mortality.

Project description:Transcriptional memory of dFOXO activity in early adulthood delays late life mortality.

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Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [ATAC-seq]

Project description:Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [ATAC-seq]

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Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [RNA-seq]

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Transcriptional memory of dFOXO activation in youth curtails later-life mortality

Project description:Identifying processes occurring in early life affect subsequent life and health span is an urgent aim to improve human health. In this study, we identified a novel mechanism of dFOXO in longevity determination in Drosophila. We found that early adulthood induction of dFOXO is sufficient to reduce mortality in old age through different pathways than chronic dFOXO. We showed that dFOXO requires specific ATP-dependent chromatin modifiers to extend lifespan, and we could mimic this lifespan extension by modulating dFOXO’s targets in later life. Furthermore, dFOXO in early life induces a specific transcriptional programme that counteracts the natural transcriptomic changes occurring with age. Our findings provide a better understanding of transcriptional mechanisms related to longevity and opens new avenues for possible time-restricted interventions to improve human health in the future.

2022-09-28 | MTBLS3251 | MetaboLights

Feedback from dFOXO in the gut and fat body

Project description:Whole fly transcript profiles of changes upon induction of dFOXO in the gut and fat body using S1106>dFOXO flies and how this response changes when the feedback to foxo is removed in the foxo null background

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ChIP-chip by array of GFP-tagged dFOXO expressed in Drosophila melanogaster adult gut and fat body

Project description:ChIP-chip by array of GFP-tagged dFOXO expressed in Drosophila melanogaster adult gut and fat body

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Genome-wide analysis of dFOXO binding sites in Drosophila

Project description:To understand how reduced insulin/IGF-1 signaling extends Drosophila lifespan through its downstream transcription factor dFOXO. We conducted ChIP analysis with a dFOXO antibody followed by Illumina high-throughput sequencing from chico heterozygous mutants, which are long-lived and normal sized, and from adult flies with ablated insulin producing cells (IPCs), which are also long-lived. dFOXO bound at promoters of 273 genes common among these genotypes, thus potentially enriching for shared factors in control of aging.

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Effect of aging and dFOXO knockout on small RNAs

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