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Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [RNA-seq]

ABSTRACT: The study examined transcriptional memory after dFOXO induction in fat body and gut of young adult female fruit flies.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE183541 | GEO | 2022/10/06

REPOSITORIES: GEO

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Transcriptional memory of dFOXO activity in early adulthood delays late life mortality [ATAC-seq]

Project description:The study examined transcriptional memory after dFOXO induction in fat body and gut of young adult female fruit flies.

2022-10-06 | GSE183540 | GEO

Transcriptional memory of dFOXO activity in early adulthood delays late life mortality.

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-06 | GSE183542 | GEO

Transcriptional memory of dFOXO activation in youth curtails later-life mortality

Project description:Identifying processes occurring in early life affect subsequent life and health span is an urgent aim to improve human health. In this study, we identified a novel mechanism of dFOXO in longevity determination in Drosophila. We found that early adulthood induction of dFOXO is sufficient to reduce mortality in old age through different pathways than chronic dFOXO. We showed that dFOXO requires specific ATP-dependent chromatin modifiers to extend lifespan, and we could mimic this lifespan extension by modulating dFOXO’s targets in later life. Furthermore, dFOXO in early life induces a specific transcriptional programme that counteracts the natural transcriptomic changes occurring with age. Our findings provide a better understanding of transcriptional mechanisms related to longevity and opens new avenues for possible time-restricted interventions to improve human health in the future.

2022-09-28 | MTBLS3251 | MetaboLights

Feedback from dFOXO in the gut and fat body

Project description:Whole fly transcript profiles of changes upon induction of dFOXO in the gut and fat body using S1106>dFOXO flies and how this response changes when the feedback to foxo is removed in the foxo null background

2014-02-05 | E-MTAB-1232 | biostudies-arrayexpress

ChIP-chip by array of GFP-tagged dFOXO expressed in Drosophila melanogaster adult gut and fat body

Project description:ChIP-chip by array of GFP-tagged dFOXO expressed in Drosophila melanogaster adult gut and fat body

2014-08-18 | E-MTAB-1021 | biostudies-arrayexpress

Genome-wide analysis of dFOXO binding sites in Drosophila

Project description:To understand how reduced insulin/IGF-1 signaling extends Drosophila lifespan through its downstream transcription factor dFOXO. We conducted ChIP analysis with a dFOXO antibody followed by Illumina high-throughput sequencing from chico heterozygous mutants, which are long-lived and normal sized, and from adult flies with ablated insulin producing cells (IPCs), which are also long-lived. dFOXO bound at promoters of 273 genes common among these genotypes, thus potentially enriching for shared factors in control of aging.

2013-09-20 | GSE44686 | GEO

Effect of aging and dFOXO knockout on small RNAs

Project description:To examine the effect of loss of dFOXO on the small RNA landscape of aging animals, we sequenced total small RNA collected from whole wildtype (wDah) and dFOXO-null (dfoxoΔ94) flies at young (5-6 days) and old (31 days) age.

2022-09-04 | GSE212493 | GEO

Effect of aging and dFOXO knockout on small RNA in Ago1 and Ago2 RNA-induced silencing complexes

Project description:To examine the effect of loss of dFOXO on Ago1 and Ago2 RISC loading in aging animals, we sequenced RNA immunoprecipitated from Ago1 and Ago2 RISC collected from whole wildtype (wDah) and dFOXO-null (dfoxoΔ94) flies at young (5 days) and old (35 days) age. dFOXO is a transcription factor that regulates Ago1 and Ago2 as well as lifespan.

2022-09-04 | GSE212492 | GEO

Transcriptional analysis of dInR and dfoxo epistasis in Drosophila melanogaster

Project description:Transcriptional analysis of dInR and dfoxo epistasis in Drosophila melanogaster. The experiment was performed to examine which parts of the transcriptional response to a reduction in insulin signalling in an adult female fly depend on the presence of the dfoxo transcription factor. Whole fly transcriptome was determined with flies over-expressing a dominant negative form of the insulin receptor, or the wild-type fly, in presence or absence of dfoxo.

2011-06-18 | E-TABM-757 | biostudies-arrayexpress

dFOXO targets in Drosophila melanogaster

Project description:dFOXO targets in adult Drosophila melanogaster females, and the effect of insulin signalling and stress on binding. The experimets determined the binding locations of dFOXO in the whole adult female fly using ChIP-chip. The protocol was validated using mock conditions: pre-immune serum or IP on chromatin from foxo null flies. The response of this binding to stress induced by treatment of flies with paraquat or by their exposure to starvation, as well as the response to an insulin-signalling-reducing genetic manipulation (over-expression of dominant negative form of the insulin receptor), was determined.

2011-06-18 | E-TABM-751 | biostudies-arrayexpress

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