Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide chromatin binding of Hdac2 in murine PDAC cells (ChIP-Seq)

ABSTRACT: Hdac2 ChIP-seq were used to determine epigenetic differences between Hdac2 knockout versus Hdac2 wildtype pancreatic cancer cells. DOI: 10.1158/0008-5472.can-20-3209

ORGANISM(S): Mus musculus

PROVIDER: GSE183823 | GEO | 2021/11/11

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Role of Hdac2 in pancreatic ductal adenocarcinoma

Project description:Microarrays were used to determine transcriptional differences between Hdac2 knockout versus Hdac2 wildtype pancreatic cancer cells.

2020-02-06 | GSE144798 | GEO

HDAC2 maintains receptor tyrosine kinase signaling of undifferentiated pancreatic cancer cells (ChIP-Seq)

Project description:H3K27ac ChIP-se and ATAC-seq were used to determine epigenetic differences between Hdac2 knockout versus Hdac2 wildtype pancreatic cancer cells.

2021-11-12 | GSE155752 | GEO

HDAC2 maintains receptor tyrosine kinase signaling of undifferentiated pancreatic cancer cells (ATAC-Seq)

Project description:H3K27ac ChIP-se and ATAC-seq were used to determine epigenetic differences between Hdac2 knockout versus Hdac2 wildtype pancreatic cancer cells.

2021-11-12 | GSE155751 | GEO

Quantitative proteomic SILAC analysis of enteroids deleted for Hdac1 or Hdac2

Project description:We have exploited organoid SILAC approaches that we have previously developed (A SILAC-Based Method for Quantitative Proteomic Analysis of Intestinal Organoids.- Gonneaud A, Jones C, Turgeon N, Lévesque D, Asselin C, Boudreau F, Boisvert FM. -Sci Rep. 2016 Nov 30;6:38195. doi: 10.1038/srep38195) to investigate proteomic changes after deletion of epigenetic eraser genes Hdac1 and Hdac2 in enteroids. Both HDAC1 and HDAC2 are epigenetic erasers that drive specific and redundant gene expression patterns, in part by removing acetyl groups on histones. Deletion of these Hdac in intestinal epithelial cell (IEC) in vivo alters intestinal homeostasis, dependent on the Hdac deleted and the level of expression of both. To determine the intrinsic specific IEC function of HDAC1 and HDAC2, we have performed transcriptomic and quantitative proteomic approaches on enteroids deficient in Hdac1 or Hdac2. We have defined changes in both mRNA and protein expression patterns affecting IEC differentiation. We have identified IEC Hdac1- and Hdac2-dependent common as well as specific pathways and biological processes. These findings uncover unrecognized similarities and differences between Hdac1 and Hdac2 in IEC.

2019-11-14 | PXD011869 | Pride

Genome-wide chromatin binding of Hdac2 in murine PDAC cells (ChIP-Seq)

Project description:Genome-wide chromatin binding of Hdac2 in murine PDAC cells (ChIP-Seq)

| PRJNA762060 | ENA

HDAC2 facilitates metastasis of pancreatic cancer cells

Project description:HDAC2 facilitates pancreatic cancer metastasis

| PRJEB47385 | ENA

HDAC in PDAC

Project description:Transcriptome analysis of murine Hdac2 knockout pancreatic tumor cells.

| PRJEB35204 | ENA

Effect of FOSL1 and HDAC2 knockdown on gene expression in cancer cell lines

Project description:We identifled FOSL1 and HDAC2 as master regulators of cancer cell metabolism. To validate their function, we knockdown FOSL1 in pancreatic adenocarcinoma cell line PANC-1 and HDAC2 in lung adenocarcinoma cell line H1299, respectively. Then RNA-seq was performed to investigate the alterations of metabolic genes.

2024-04-27 | GSE230729 | GEO

Role of Hdac2 in pancreatic ductal adenocarcinoma

Project description:Role of Hdac2 in pancreatic ductal adenocarcinoma

| PRJNA604969 | ENA

Murine PDAC cell lines

Project description:Expression profiles of 28 murine pancreatic cancer cell lines isolated from a KrasG12D-based mouse model of pancreatic cancer mRNA of 28 low passaged murine pancreatic cancer cell lines was extracted and hybridized to Affymetrix microarrays

2012-09-06 | E-GEOD-40609 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data