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Immune profiles and DNA methylation alterations related to non-muscle-invasive bladder cancer outcomes

ABSTRACT: Non-muscle-invasive bladder cancer (NMIBC) patients receive frequent monitoring because ≥ 70% will have recurrent disease. However, screening is invasive, expensive, and associated with significant morbidity making bladder cancer the most expensive cancer to treat per capita. There is an urgent need to expand the understanding of markers related to recurrence and survival outcomes of NMIBC. Our results expand on the knowledge of immune profiles and methylation alteration associated with NMIBC outcomes and represent a first step toward the development of DNA methylation-based biomarkers of tumor recurrence.

ORGANISM(S): Homo sapiens

PROVIDER: GSE183920 | GEO | 2022/02/01

REPOSITORIES: GEO

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