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The mechanistic studies of GATA1 regulation of SREBP2 in G1-ER4 cells

ABSTRACT: In our work, we uncovered a critical role for cholesterol homeostasis in terminal erythropoiesis. The master transcriptional factor GATA1 binds to Sterol-regulatory element binding protein 2 (SREBP2) to downregulate cholesterol biosynthesis, leading to a gradual reduction in intracellular cholesterol levels. To reveal genetic interactions and epistatic relations between GATA1 and SREBP2 on depth at the whole genome level, we performed RNA sequencing to analyze the gene expression profiles change between treated with Vehicle or β-estradiol in overexpressing active SREBP2 G1E-ER4 cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE184002 | GEO | 2022/02/08

REPOSITORIES: GEO

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