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CRSPR/Cas9 gene knockout screen identifies colorectal cancer dependency on cryptic open reading frames

ABSTRACT: Emerging evidence suggests that the cryptic translation beyond the annotated translatome may yield proteins with important function. However, the role and function mechanism of these cryptic ORFs in complex diseases such as cancer remain largely unknown. To fill this gap, we combined ribosome profiling and CRISPR/Cas9 screen to systematically identify the colorectal cancer (CRC) dependency on cryptic ORFs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE184322 | GEO | 2023/08/06

REPOSITORIES: GEO

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