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Conditional deletion of HIF-2α in mouse nucleus pulposus reduces fibrosis and provides mild and transient protection from age-dependent structural changes in intervertebral disc

ABSTRACT: Hypoxia inducible factors (HIFs) are critical to the development and homeostasis of the intervertebral disc. While HIF-2α, one of the main HIF-α isoforms is expressed in nucleus pulposus (NP) cells, its functions remain unknown. We used microarrays to explore the transcriptomics of differentially expressed genes between control and HIF-2α cKO NP cells in 6M and 14M mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE184424 | GEO | 2024/09/16

REPOSITORIES: GEO

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Increased HIF-2α Activity in the Nucleus Pulposus Causes Mild Degenerative Changes in the Intervertebral Disc in the Aging Mouse Spine

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| PRJNA1051119 | ENA

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