Transcriptomics

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Organ-differential Regulation of Vascular Development by DEAD-box Helicase 24


ABSTRACT: The goal of this study is to understand the molecular mechanisms of DDX24 organ-differentially regulates vascular development, we sequenced the DDX24 or control siRNA transfected HUVECs and HCMECs. We compared the expression levels of many genes involved in angiogenesis such as VEGF, Wnt and Notch signaling, these genes not consistent alterations in HUVEC and HCMEC. HUVEC is mainly an up-regulation of the VEGF pathway, while HCMEC shows a down-regulation of the Wnt pathway.

ORGANISM(S): Homo sapiens

PROVIDER: GSE185261 | GEO | 2021/10/08

REPOSITORIES: GEO

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