Methylation profiling

Dataset Information

0

Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing


ABSTRACT: The Oxford Nanopore (ONT) platform provides portable and rapid genome sequencing, and its ability to natively profile DNA methylation without complex sample processing is attractive for clinical sequencing. We recently demonstrated ONT shallow whole-genome sequencing to detect copy number alterations (CNA) from the circulating tumor DNA (ctDNA) of cancer patients. Here, we show that cell-type and cancer-specific methylation changes can also be detected, as well as cancer-associated fragmentation signatures. This feasibility study suggests that ONT shallow WGS could be a powerful tool for liquid biopsy, especially real-time medical applications.

ORGANISM(S): Homo sapiens

PROVIDER: GSE185307 | GEO | 2022/04/27

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-11-17 | E-MTAB-10548 | biostudies-arrayexpress
2019-03-14 | E-MTAB-7778 | biostudies-arrayexpress
2019-12-15 | GSE141641 | GEO
2023-07-19 | GSE218035 | GEO
2020-06-18 | GSE151841 | GEO
2020-06-18 | GSE151984 | GEO
2021-10-27 | GSE185917 | GEO
2023-05-19 | GSE232842 | GEO
2022-05-12 | GSE149117 | GEO
| PRJEB22076 | ENA