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Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [Human KC]

ABSTRACT: To investigate the human primary Kupffer cells from NAFLD patients response to DPI in vitro.

ORGANISM(S): Homo sapiens

PROVIDER: GSE186326 | GEO | 2021/10/23

REPOSITORIES: GEO

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Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [mouse KC]

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Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [Human KC]

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Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [single-cell RNA-seq]

Project description:Single-cell RNAseq analysis of liver cells from NASH and cirrhosis patients has identified the presence of TREM2+ disease-associated macrophages (DAMs) in the liver that display lower expression of metabolic genes. To determine whether the DAMs are also present in patient with mild NFALD, we performed scRNAseq of freshly isolated immune cells from liver biopsies of 3 healthy donors and 3 mild NFALD patients. Kupffer cells were specifically focused.

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Project description:This SuperSeries is composed of the SubSeries listed below.

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A human iPSC-derived multilineage liver organoid model containing Kupffer cells to study human sepsis-associated liver dysfunction [hiPSC-EMP-KC-pKC]

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microRNA profiles in KC (Kupffer cells) and MNCs (blood monocytes):

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microRNA profiles in KC (Kupffer cells) after partial hepatoctomy

Project description:microRNA profiles in KC (Kupffer cells) after partial hepatoctomy

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