Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE186329 | GEO | 2021/10/23

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [mouse KC]

Project description:To investigate the transcriptional changes of Kupffer cells isolated from HFD-induced obesity mice treated with DPI in vivo.

2021-10-23 | GSE186327 | GEO

Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [Human KC]

Project description:To investigate the human primary Kupffer cells from NAFLD patients response to DPI in vitro.

2021-10-23 | GSE186326 | GEO

Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [single-cell RNA-seq]

Project description:Single-cell RNAseq analysis of liver cells from NASH and cirrhosis patients has identified the presence of TREM2+ disease-associated macrophages (DAMs) in the liver that display lower expression of metabolic genes. To determine whether the DAMs are also present in patient with mild NFALD, we performed scRNAseq of freshly isolated immune cells from liver biopsies of 3 healthy donors and 3 mild NFALD patients. Kupffer cells were specifically focused.

2021-10-23 | GSE186328 | GEO

Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells

Project description:Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells

| PRJNA773400 | ENA

Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [Human KC]

Project description:Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [Human KC]

| PRJNA773403 | ENA

Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [mouse KC]

Project description:Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [mouse KC]

| PRJNA773407 | ENA

Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [single-cell RNA-seq]

Project description:Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [single-cell RNA-seq]

| PRJNA773406 | ENA

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation.

Project description:Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis; however, the precise mechanism by which metabolic reprogramming regulates the inflammatory response is unclear. Here we show that aerobic glycolysis contributes to sepsis by modulating inflammasome activation in macrophages. PKM2-mediated glycolysis promotes inflammasome activation by modulating EIF2AK2 phosphorylation in macrophages. Pharmacological and genetic inhibition of PKM2 or EIF2AK2 attenuates NLRP3 and AIM2 inflammasomes activation, and consequently suppresses the release of IL-1β, IL-18 and HMGB1 by macrophages. Pharmacological inhibition of the PKM2-EIF2AK2 pathway protects mice from lethal endotoxemia and polymicrobial sepsis. Moreover, conditional knockout of PKM2 in myeloid cells protects mice from septic death induced by NLRP3 and AIM2 inflammasome activation. These findings define an important role of PKM2 in immunometabolism and guide future development of therapeutic strategies to treat sepsis.

| S-EPMC5093342 | biostudies-literature

SF3B1 promotes glycolysis and tumor malignancy through splicing-independent activation of HIF1α

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-06-22 | GSE201462 | GEO

A genomic landscape of enhanced bovine pluripotency

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-05-07 | E-GEOD-63054 | biostudies-arrayexpress