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Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [mouse KC]

ABSTRACT: To investigate the transcriptional changes of Kupffer cells isolated from HFD-induced obesity mice treated with DPI in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE186327 | GEO | 2021/10/23

REPOSITORIES: GEO

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Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [Human KC]

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Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [Human KC]

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Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [single-cell RNA-seq]

Project description:Single-cell RNAseq analysis of liver cells from NASH and cirrhosis patients has identified the presence of TREM2+ disease-associated macrophages (DAMs) in the liver that display lower expression of metabolic genes. To determine whether the DAMs are also present in patient with mild NFALD, we performed scRNAseq of freshly isolated immune cells from liver biopsies of 3 healthy donors and 3 mild NFALD patients. Kupffer cells were specifically focused.

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Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells

Project description:This SuperSeries is composed of the SubSeries listed below.

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Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [single-cell RNA-seq]

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A human iPSC-derived multilineage liver organoid model containing Kupffer cells to study human sepsis-associated liver dysfunction [hiPSC-EMP-KC-pKC]

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microRNA profiles in KC (Kupffer cells) and MNCs (blood monocytes):

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