Transcriptomics

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Age-related changes of gene expression profiles in Drosophila


ABSTRACT: An individual’s gene expression profile changes throughout life. This change in gene expression is shaped by differences in physiological needs and functions between the younger and older organism. Here we report a transcriptomic analysis of Drosophila melanogaster using microarrays. We compared the expression profiles of two-day-old female adult flies with those of 45-day-old flies. We identified 1184 genes with pronounced expression level differences between young and old age groups. Most genes involved in muscle development/maintenance that display different levels of expression with age were downregulated in older flies. Many of these genes contributed to sarcomere formation and function. Several of these genes were functionally related to direct and indirect flight muscles; some of them were exclusively expressed in these muscles. Conversely, several genes involved in apoptosis processes were upregulated in aging flies. Close to half of these genes, such as different caspases, promote cell death, whereas the other half is associated with the inhibition of apoptosis. Several genes that inhibit apoptosis contribute to cell-type maintenance for different cell groups, including neurons, cardiac cells, and salivary gland cells. In addition, several genes involved in resistance to toxic chemicals were upregulated in aging flies, which is consistent with a global upregulation of the defense response system in aging flies. Finally, 232 of the differentially expressed genes had no known functions.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE187896 | GEO | 2021/12/10

REPOSITORIES: GEO

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