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Whole blood gene expression profiles associated with mortality in community-acquired pneumonia

ABSTRACT: We aimed to examine the differences in the gene expression profile in peripheral blood at hospital admission between patients with community-acquired pneumonia (CAP) who died and survived during hospitalization. Whole blood samples for genome expression profile analysis were obtained within 24 hours of hospital admission. Gen set enrichment analysis (GSEA) identified gene sets positively enriched in the patients who survived, mainly related with interferon- alpha response, apoptosis, and sex hormones pathways. Similarly, GSEA identified gene sets positively enrichment for the patients who died (oxidative stress, endoplasmic reticulum stress, oxidative phosphorylation, and angiogenesis pathways).

ORGANISM(S): Homo sapiens

PROVIDER: GSE188309 | GEO | 2022/10/17

REPOSITORIES: GEO

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