Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Rattus norvegicus

PROVIDER: GSE190613 | GEO | 2022/10/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [rat]

Project description:Rodents perceive pheromones via vomeronasal receptors encoded by the Vr and Fpr gene superfamilies. The evolution of these latter is exceptionally dynamic. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered organization of functional V1r and Fpr genes. We also found that V1r pseudogenes are more likely to be expressed when located in a functional V1r gene cluster than when isolated. To explore the potential regulatory role played by the association of functional vomeronasal receptor genes with their clusters, we dissociated the mouse Fpr-rs3 from its native cluster via transgenesis. Singular and specific transgenic Fpr-rs3 transcription was observed in young vomeronasal neurons, but was only transient. Our data point to the existence of transcription stabilizing elements not coupled to vomeronasal gene units but rather associated with vomeronasal gene clusters, and thus explain the evolutionary conserved clustered organization of functional vomeronasal genes.

2022-10-02 | GSE190612 | GEO

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [mouse]

2022-10-02 | GSE190611 | GEO

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [scRNA-seq]

2022-10-02 | GSE193024 | GEO

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes

Project description:Transcriptional instability prevents dispersion of functional vomeronasal receptor genes

| PRJNA787885 | ENA

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [mouse]

Project description:Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [mouse]

| PRJNA787890 | ENA

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [rat]

Project description:Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [rat]

| PRJNA787889 | ENA

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [scRNA-seq]

Project description:Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [scRNA-seq]

| PRJNA794152 | ENA

First evidence for functional vomeronasal 2 receptor genes in primates.

Project description:Two classes of vomeronasal receptor genes, V1R and V2R, occur in vertebrates. Whereas, V1R loci are found in a wide variety of mammals, including primates, intact V2R genes have thus far only been described in rodents and marsupials. In primates, the V2R repertoire has been considered degenerate. Here, we identify for the first time two intact V2R loci in a strepsirrhine primate, the grey mouse lemur (Microcebus murinus), and demonstrate their expression in the vomeronasal organ. Putatively functional orthologues are present in two other strepsirrhines, whereas, both loci are pseudogenes in a range of anthropoid species. The functional significance of the loci is unknown, but positive selection on one of them is consistent with an adaptive role in pheromone detection. Finally, conservation of V2R loci in strepsirrhines is notable, given their high diversity and role in MUP and MHC detection in rodents.

| S-EPMC3565523 | biostudies-literature

Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.

Project description:Rodents perceive pheromones via vomeronasal receptors encoded by highly evolutionarily dynamic Vr and Fpr gene superfamilies. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered organization of functional V1r and Fpr genes. We also found that V1r pseudogenes are more likely to be expressed when located in a functional V1r gene cluster than when isolated. To explore the potential regulatory role played by the association of functional vomeronasal receptor genes with their clusters, we dissociated the mouse Fpr-rs3 from its native cluster via transgenesis. Singular and specific transgenic Fpr-rs3 transcription was observed in young vomeronasal neurons but was only transient. Our study of natural and artificial dispersed gene duplications uncovers the existence of transcription-stabilizing elements not coupled to vomeronasal gene units but rather associated with vomeronasal gene clusters and thus explains the evolutionary conserved clustered organization of functional vomeronasal genes.

| S-EPMC9668312 | biostudies-literature

ZEB1 expression prevents DNA replication stress in cancer stem cells and delays chromosomal instability

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-12-31 | E-GEOD-56031 | biostudies-arrayexpress