Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [mouse]

ABSTRACT: Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [mouse]

PROVIDER: PRJNA787890 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes

Project description:Transcriptional instability prevents dispersion of functional vomeronasal receptor genes

| PRJNA787885 | ENA

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [rat]

Project description:Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [rat]

| PRJNA787889 | ENA

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [scRNA-seq]

Project description:Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [scRNA-seq]

| PRJNA794152 | ENA

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [rat]

Project description:Rodents perceive pheromones via vomeronasal receptors encoded by the Vr and Fpr gene superfamilies. The evolution of these latter is exceptionally dynamic. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered organization of functional V1r and Fpr genes. We also found that V1r pseudogenes are more likely to be expressed when located in a functional V1r gene cluster than when isolated. To explore the potential regulatory role played by the association of functional vomeronasal receptor genes with their clusters, we dissociated the mouse Fpr-rs3 from its native cluster via transgenesis. Singular and specific transgenic Fpr-rs3 transcription was observed in young vomeronasal neurons, but was only transient. Our data point to the existence of transcription stabilizing elements not coupled to vomeronasal gene units but rather associated with vomeronasal gene clusters, and thus explain the evolutionary conserved clustered organization of functional vomeronasal genes.

2022-10-02 | GSE190612 | GEO

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [mouse]

2022-10-02 | GSE190611 | GEO

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes [scRNA-seq]

2022-10-02 | GSE193024 | GEO

Transcriptional instability prevents dispersion of functional vomeronasal receptor genes

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-02 | GSE190613 | GEO

Pronounced Strain-Specific Chemosensory Receptor Gene Expression in the Mouse Vomeronasal Organ

Project description:Our study reports strain specific expression and abensce of sexual dimorphic expression in mouse vomeronasal epithelial tissue

2017-12-05 | GSE99684 | GEO

Yeast EndoG prevents genome instability by degrading extranuclear DNA species

Project description:Yeast EndoG prevents genome instability by degrading extranuclear DNA species

| PRJNA1033160 | ENA

Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability

Project description:Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability

| PRJNA629771 | ENA