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RB-N phosphorylation promotes BRD4-mediated CREB signaling hyperactivation and BET inhibitor resistance

ABSTRACT: The combination of CREB inhibitor and JQ1 could overcome the resistance to BET inhibitors in RB loss prostate cancer. Our study firstly showed that GNB1L-CREB pathway was activated after RB loss and considered as the potential target for the prostate cancer therapy

ORGANISM(S): Homo sapiens

PROVIDER: GSE191263 | GEO | 2022/08/30

REPOSITORIES: GEO

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