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Differential Expression Profiles of tRNA-derived Small RNAs in Muscle-Invasive Bladder Cancer in Chinese Population

ABSTRACT: The goals of this study are to screen differential expression profiles of tRNA-Derived small RNAs (tsRNAs) in muscle-invasive bladder cancer (MIBC) in Chinese population using next-generation sequencing and qRT-PCR.As a result, in MIBC tissues, 406 tsRNAs were differentially expressed between in MIBC tissues. Of them, 91 tsRNAs were significantly differentially expressed (fold change>1.5; P<0.05): 65 tsRNAs were significantly up-regulated whereas 26 were significantly down-regulated in MIBC.Taken together,this study explored, for the first time, the significant alteration of tsRNA expression profiles in MIBC in Chinese population and offered deep insights into many possible treatment targets of MIBC by regulating tsRNAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE192651 | GEO | 2022/04/27

REPOSITORIES: GEO

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