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Transcriptomic analysis of HCV+ vs HCV- hepatocytes and tumoral cells

ABSTRACT: HCV+ cells were detected by smiFISH on liver section of a patient with hepatocellular carcinoma. Clusters of HCV+ and HCV- cells were captured by laser microdissection and transriptomes analysed by RNA sequening. Highly sensitive single molecule fluorescent in situ hybridization applied to frozen tissue sections of a hepatitis C patient allowed the delineation of clusters of infected hepatocytes. Laser micro-dissection followed by RNAseq analysis of HCV-positive and -negative regions from the tumoral and non-tumoral tissues from the same patient revealed HCV-related deregulation of expression of genes in the tumor and in the non-tumoral tissue.

ORGANISM(S): Homo sapiens

PROVIDER: GSE192862 | GEO | 2022/01/31

REPOSITORIES: GEO

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