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The ZFP36 family of RNA-binding proteins regulates homeostatic and autoreactive T cell responses [mRNA-decaySeq]

ABSTRACT: These are CD44hi CD4 T splenic T cells from the indicated mice activated in vitro with anti-CD3/anti-CD28 for 24 hours. Following activation, cells were treated with Actinomycin D for the indicated time course.

ORGANISM(S): Mus musculus

PROVIDER: GSE192954 | GEO | 2022/08/09

REPOSITORIES: GEO

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The ZFP36 family of RNA-binding proteins regulates homeostatic and autoreactive T cell responses [RNA-Seq]

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The ZFP36 family of RNA-binding proteins regulates homeostatic and autoreactive T cell responses

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Project description:Analysis of anti-CD3/anti-CD28 stimulated T cells treated with or without nickel chloride. Nickel is the most important contact allergen in the general population of the industrialized world. Results provide insight into the biological effects of nickel on human CD3+ T cells. We obtained mRNA of purified human CD3+ T cells from 3 different donors that were treated with or without 1000 μM nickel chloride for 1 h and then stimulated with anti-CD3/anti-CD28 for 6 h.

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