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Small RNA sequencing of perilesional cortex and ipsilateral thalamus at 3-months after lateral fluid-percussion injury or sham-operation

ABSTRACT: At 3-months after after traumatic brain injury, small RNA sequencing was performed on samples from ipsilateral thalamus and perilesional cortex of selected rats with the chronic inflammatory endophenotype, and sham-operated controls.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE192980 | GEO | 2022/01/26

REPOSITORIES: GEO

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mRNA sequencing of perilesional cortex and ipsilateral thalamus at 3-months after lateral fluid-percussion injury or sham-operation

Project description:At 3-months after after traumatic brain injury, messenger RNA sequencing was performed on samples from ipsilateral thalamus and perilesional cortex of selected rats with the chronic inflammatory endophenotype, and sham-operated controls.

2022-01-26 | GSE192979 | GEO

mRNA sequencing of perilesional cortex and ipsilateral thalamus at 3-months after lateral fluid-percussion injury or sham-operation

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Small RNA sequencing of perilesional cortex and ipsilateral thalamus at 3-months after lateral fluid-percussion injury or sham-operation

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mRNA-seq and miRNA-seq of perilesional cortex and ipsilateral thalamus at 3-months after lateral fluid-percussion injury or sham-operation

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mRNA-seq and miRNA-seq of perilesional cortex and ipsilateral thalamus at 3-months after lateral fluid-percussion injury or sham-operation

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Project description:TBI was induced with lateral fluid-percussion injury in adult male rats. MBD-seq of the perilesional cortex, ipsilateral thalamus and ipsilateral hippocampus was performed at 3 months post-TBI. The data was used to identify differential methylation of gene promoter, gene body, and exons in the perilesional cortex , thalamus and hippocampus.

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Project description:TBI was induced with lateral fluid-percussion injury in adult male rats. Genome-wide RNA-seq of the perilesional cortex, ipsilateral thalamus and dorsal hippocampus was performed at 3 months post-TBI. The data highlighted chronic transcriptional changes, particularly, in the perilesional cortex and thalamus. Genes showing a significantly altered expression both in the cortex and thalamus were submitted to the LINCS web query to identify novel pharmacotherapies to improve post-TBI outcome.

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