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Liver colonisation by colorectal cancer metastases requires YAP-controlled plasticity at the micrometastatic stage

ABSTRACT: Human engineered CRC organoids were equipped with the intestinal stem cell reporter STAR reflecting transcriptional activity of ASCL2. Successfully growing organoids display heterogeneous STAR expression and grow into big structures, while growth-compromised organoids stay small and are either entirely STAR-pos or STAR-neg.

ORGANISM(S): Homo sapiens

PROVIDER: GSE193248 | GEO | 2022/02/23

REPOSITORIES: GEO

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