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Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neuron

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE196212 | GEO | 2023/09/12

REPOSITORIES: GEO

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Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons.

Project description:The expression of linear DNA sequence is precisely regulated by the three-dimensional (3D) architecture of chromatin. Morphine-induced aberrant gene networks of neurons have been extensively investigated; however, how morphine impacts the 3D genomic architecture of neurons is still unknown. Here, we applied digestion-ligation-only high-throughput chromosome conformation capture (DLO Hi-C) technology to investigate the effects of morphine on the 3D chromatin architecture of primate cortical neurons. After receiving continuous morphine administration for 90 days on rhesus monkeys, we discovered that morphine re-arranged chromosome territories, with a total of 391 segmented compartments being switched. Morphine altered over half of the detected topologically associated domains (TADs), most of which exhibited a variety of shifts, followed by separating and fusing types. Analysis of the looping events at kilobase-scale resolution revealed that morphine increased not only the number but also the length of differential loops. Moreover, all identified differentially expressed genes from the RNA sequencing data were mapped to the specific TAD boundaries or differential loops, and were further validated for changed expression. Collectively, an altered 3D genomic architecture of cortical neurons may regulate the gene networks associated with morphine effects. Our finding provides critical hubs connecting chromosome spatial organization and gene networks associated with the morphine effects in humans.

| S-EPMC10787020 | biostudies-literature

Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neuron [HiC]

Project description:Purpose:The goals of this study are to investigate the 3D chromatin architecture of cortical neurons in rhesus monkeys treated with morphine for 90 days using digestion-ligation-only high-throughput chromosome conformation capture technology combined with transcriptome profiling (RNA-seq).

2023-09-12 | GSE196209 | GEO

Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neuron [RNA-seq]

Project description:Purpose: The goals of this study are to investigate the 3D chromatin architecture of cortical neurons in rhesus monkeys treated with morphine for 90 days using digestion-ligation-only high-throughput chromosome conformation capture technology combined with transcriptome profiling (RNA-seq).

2023-09-12 | GSE196210 | GEO

Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neuron

Project description:Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neuron

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Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neuron [HiC]

Project description:Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neuron [HiC]

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Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neuron [RNA-seq]

Project description:Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neuron [RNA-seq]

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The impact of neuron morphology on cortical network architecture.

Project description:The neurons in the cerebral cortex are not randomly interconnected. This specificity in wiring can result from synapse formation mechanisms that connect neurons, depending on their electrical activity and genetically defined identity. Here, we report that the morphological properties of the neurons provide an additional prominent source by which wiring specificity emerges in cortical networks. This morphologically determined wiring specificity reflects similarities between the neurons' axo-dendritic projections patterns, the packing density, and the cellular diversity of the neuropil. The higher these three factors are, the more recurrent is the topology of the network. Conversely, the lower these factors are, the more feedforward is the network's topology. These principles predict the empirically observed occurrences of clusters of synapses, cell type-specific connectivity patterns, and nonrandom network motifs. Thus, we demonstrate that wiring specificity emerges in the cerebral cortex at subcellular, cellular, and network scales from the specific morphological properties of its neuronal constituents.

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MYT1L deficiency impairs excitatory neuron trajectory during cortical development

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-04-10 | GSE262368 | GEO

Evolution of regulatory signatures in primate cortical neurons at cell-type resolution

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-10-03 | GSE158934 | GEO

STAG2 Mutations Reshape the Cohesin-Structured Spatial Chromatin Architecture to Drive Gene Regulation in Acute myeloid Leukemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-18 | GSE268035 | GEO