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ScRNA-seq of in vitro differentiated D6 mPGCLCs

ABSTRACT: Germ cell specification is an elusive biological event, as it occurs in a small group of cells in the very early embryo (E6.5). In vitro differentiation of naive mouse Embryonic Stem Cells (mESCs) to mouse Primordial Germ Cell like cells (mPGCLCs) allows the mechanistic investigation of germ cell specification. The goal of this study is to profile of gene expression via single cell RNA sequencing throughout the differentiation protocol. In particular, this project aims at examining the transcriptional activation of the molecular networks that direct the epigenetic reprogramming of mPGCLCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE197335 | GEO | 2022/10/15

REPOSITORIES: GEO

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scRNA-seq of in vitro differentiated D6 mPGCLCs

Project description:scRNA-seq of in vitro differentiated D6 mPGCLCs

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