Human iPS cell-derived cartilage spatially and functionally replaces nucleus pulposus
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ABSTRACT: Single cell RNA sequencing (scRNA-seq) analysis identified notochordal nucleus pulposus (NP) cells and chondrocyte-like NP cells in NP. Cells in human induced pluripotent stem cell-derived cartilage (hiPS-Cart) corresponded to chondrocyte-like NP cells but not to notochordal NP cells. hiPS-Cart cells changed their profile after implantation into intervertebral disks of nude rats, differentiating into two lineages that are metabolically distinct from each other. However, post-implanted hiPS-Cart cells corresponded to chondrocyte-like NP cells only and did not develop into notochordal NP cells.
ORGANISM(S): Homo sapiens Macaca fascicularis
PROVIDER: GSE197380 | GEO | 2022/11/28
REPOSITORIES: GEO
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