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5' UTR-dependent m6A methylation regulates aging and circadian rhythms in Drosophila [RNA-seq whole]

ABSTRACT: To evoke further attention to the potential hazard of increasingly accumulative blue light exposure, we construct a series of in vivo Drosophila models employed for multi-omics analyses. This project includes the RNA-seq data of w1118 F1 generation male adult whole flies.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE197382 | GEO | 2023/11/08

REPOSITORIES: GEO

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5' UTR-dependent m6A methylation regulates aging and circadian rhythms in Drosophila [RNA-seq head]

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5' UTR-dependent m6A methylation regulates aging and circadian rhythms in Drosophila [RIP-seq whole]

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<i>Period2</i> 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.

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5' UTR-dependent m6A methylation regulates aging and circadian rhythms in Drosophila

Project description:This SuperSeries is composed of the SubSeries listed below.

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Circadian rhythms regulate amelogenesis.

Project description:Ameloblasts, the cells responsible for making enamel, modify their morphological features in response to specialized functions necessary for synchronized ameloblast differentiation and enamel formation. Secretory and maturation ameloblasts are characterized by the expression of stage-specific genes which follows strictly controlled repetitive patterns. Circadian rhythms are recognized as key regulators of the development and diseases of many tissues including bone. Our aim was to gain novel insights on the role of clock genes in enamel formation and to explore the potential links between circadian rhythms and amelogenesis. Our data shows definitive evidence that the main clock genes (Bmal1, Clock, Per1 and Per2) oscillate in ameloblasts at regular circadian (24 h) intervals both at RNA and protein levels. This study also reveals that the two markers of ameloblast differentiation i.e. amelogenin (Amelx; a marker of secretory stage ameloblasts) and kallikrein-related peptidase 4 (Klk4, a marker of maturation stage ameloblasts) are downstream targets of clock genes. Both, Amelx and Klk4 show 24h oscillatory expression patterns and their expression levels are up-regulated after Bmal1 over-expression in HAT-7 ameloblast cells. Taken together, these data suggest that both the secretory and the maturation stages of amelogenesis might be under circadian control. Changes in clock gene expression patterns might result in significant alterations of enamel apposition and mineralization.

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