Transcriptomics

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Characterization of Mycobacterium smegmatis SigF regulon


ABSTRACT: Mycobacterium smegmatis SigF is a group III sigma factor. Its ortholog in M. tuberculosis is reported to have role in regulation and function of cell wall components. In present study we have created an M. smegmatis ΔsigF mutant by allele exchange method. M. smegmatis sigF mutant shows non pigmented phenotype and is more sensitive to hydrogen peroxide generated oxidative stress. DNA microarray analysis of M. smegmatis wild type and ΔsigF mutant suggests that SigF in this species controls the expression of several energy and central intermediary metabolism genes along with regulation of carotenoid biosynthesis.

ORGANISM(S): Mycolicibacterium smegmatis MC2 155

PROVIDER: GSE19774 | GEO | 2010/08/20

SECONDARY ACCESSION(S): PRJNA121857

REPOSITORIES: GEO

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