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Runx3 drives a tissue-residency program that is absent in CD4+ T cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE198612 | GEO | 2022/05/24

REPOSITORIES: GEO

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Runx3 drives a tissue residency program that is absent in CD4+ T cells [ATAC-seq]

Project description:Tissue-resident memory T (TRM) cells provide rapid and superior control of localized infections. The transcription factor Runx3 was recently identified as a master regulator of CD8+ T cell tissue residency. However, Runx3 also drives CD8+ T cell lineage commitment and is repressed in CD4+ T cells, raising the possibility that this transcription factor defines a form of tissue residency unique to the CD8+ T cell subset. Here, we show that as a direct consequence of Runx3-deficiency, CD4+ TRM cells in epithelia lack the TGFb-responsive transcriptional network that underpins CD8+ TRM cell residency. Ectopic Runx3 expression in CD4+ T cells rescued this transcriptional program to promote prolonged survival, decreased tissue egress and a microanatomical redistribution towards epithelial layers that combined, resulted in superior local immune protection. Our results thus reveal a mechanistic discordance between CD4+ and CD8+ TRM cell formation in barrier tissues that is controlled by Runx3. Consequently, CD4+ TRM cells are unable to adopt a type of tissue residency that is intrinsically accessible to the CD8+ TRM cell subset.

2022-05-24 | GSE198611 | GEO

Runx3 drives a tissue-residency program that is absent in CD4+ T cells [RNA-seq]

Project description:Pattens of tissue-residency differs between CD4+ and CD8+ memory T cells in evironmentally exposed organs. The lineage-controlling transcription factor Runx3, expressed in CD8+ T cells, is responsible for shaping a tissue-resident gene network in response to the cytokine TGF-b. While the lack of Runx3 by CD4+ T cells precludes these transcriptional changes, Runx3-overexpression in CD+ T cells enable phenotypical, transcriptional and functional changes to allow residency.

2022-05-24 | GSE182511 | GEO

Runx3 drives a tissue-residency program that is absent in CD4+ T cells

Project description:Runx3 drives a tissue-residency program that is absent in CD4+ T cells

| PRJNA816144 | ENA

Runx3 drives a tissue-residency program that is absent in CD4+ T cells [RNA-seq]

Project description:Runx3 drives a tissue-residency program that is absent in CD4+ T cells [RNA-seq]

| PRJNA756546 | ENA

Runx3 drives a tissue residency program that is absent in CD4+ T cells [ATAC-seq]

Project description:Runx3 drives a tissue residency program that is absent in CD4+ T cells [ATAC-seq]

| PRJNA816148 | ENA

Runx3 regulated genes in splenic CD4+ dendritic cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-06-22 | E-GEOD-48591 | biostudies-arrayexpress

The transcription program of Runx3 in natural killer cells and CD8+ T cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-11-18 | E-GEOD-50131 | biostudies-arrayexpress

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-12-15 | GSE107395 | GEO

Runx3 regulated genes in splenic CD4+ dendritic cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-06-22 | GSE48591 | GEO

Metabolic Programs of T Cell Tissue Residency Empower Tumor Immunity

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-10 | GSE207044 | GEO

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