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The transcription program of Runx3 in natural killer cells and CD8+ T cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Joseph Lotem

PROVIDER: E-GEOD-50131 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Runx3-mediated transcriptional program in cytotoxic lymphocytes.

Lotem Joseph J Levanon Ditsa D Negreanu Varda V Leshkowitz Dena D Friedlander Gilgi G Friedlander Gilgi G Groner Yoram Y

PloS one 20131113 11

The transcription factor Runx3 is highly expressed in CD8(+) T and NK cytotoxic lymphocytes and is required for their effective activation and proliferation but molecular insights into the transcription program regulated by Runx3 in these cells are still missing. Using Runx3-ChIP-seq and transcriptome analysis of wild type vs. Runx3(-/-) primary cells we have now identified Runx3-regulated genes in the two cell types at both resting and IL-2-activated states. Runx3-bound genomic regions in both ...[more]

PMID: 24236182

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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