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Gene expression profiles of variants of B16OVA melanoma cells established from different host immunological conditions

ABSTRACT: To establish cancer cells escaping from host immunity, we used murine B16 melanoma cell line expressing ovalbumin (B16OVA) and inoculated into mice immunized with OVA. Using this model, we established cell lines after the in vivo passage through distinct immunological condition. B16OVA tumor exposed to OVA-specific CD8+ T cell immunity in OVA-immunized B6 mice were isolated and established five variants (IMM1, 2, 8). For comparison, B16OVA tumors from non-immunized naïve B6 mice or OVA-immunized IFN-gamma-deficient mice were also isolated and established four variants, namely NIMM (1, 3, 4) cell lines or GKO-IMM (1, 2, 3) cell lines, respectively.

ORGANISM(S): Mus musculus

PROVIDER: GSE199573 | GEO | 2022/03/29

REPOSITORIES: GEO

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