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ATAC-seq of bone marrow neutrophil treated PGE2 or Vehicle

ABSTRACT: Purpose: Investigate the gene accessibility change of neutrophils from PGE2 stimulation and identify the posibility for PGE2 could induce lung neutrophil like characteristics. Methods: Isolated bone marrow neutrophils with Percoll gradient are treated with 10 μM of PGE2 for 24 hours. Conclusion: Chromatin accessibility for the genes that were upregulated in lung neutrophils and PGE2 treated neutrophils were increased, so PGE2 could induce lung neutrophil like characteristics with change chromatin accessibility.

ORGANISM(S): Mus musculus

PROVIDER: GSE199772 | GEO | 2022/08/01

REPOSITORIES: GEO

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