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Refining Colorectal Cancer Classification and Clinical Stratification Through a Single-Cell Atlas

ABSTRACT: To determine and dissect the extent of tumor, immunological, and stromal heterogeneity in CRC patients, we performed droplet-based scRNA-seq on 16 racially diverse, treatment naïve CRC patient tissue samples and seven adjacent normal colonic tissue samples (totaling 23 samples), yielded 49,589 single cells enabling high-resolution depiction of the cellular diversity and heterogeneity within the tumor and microenvironmental cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE200997 | GEO | 2022/04/19

REPOSITORIES: GEO

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