Transcriptomics

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Gene expression profile of bone marrow cells from leukemic mice by transduction of synonymous mutant of MLL-AF4


ABSTRACT: The establishment of a murine disease model of MLL-AF4 via retroviral transduction has been difficult due to a lack of understanding of its unknown regulatory mechanisms. We showed that MLL-AF4 protein is post-transcriptionally regulated, and its synonymous mutant is able to induce myeloid leukemia by retroviral transduction. To validate synonymous mutant of MLL-AF4 is phenotypically similar to the MLL-mAf4, we analyzed the gene expression profiles by RNA-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE201503 | GEO | 2022/10/20

REPOSITORIES: GEO

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