Gene expression profile of bone marrow cells from leukemic mice by transduction of synonymous mutant of MLL-AF4
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ABSTRACT: The establishment of a murine disease model of MLL-AF4 via retroviral transduction has been difficult due to a lack of understanding of its unknown regulatory mechanisms. We showed that MLL-AF4 protein is post-transcriptionally regulated, and its synonymous mutant is able to induce myeloid leukemia by retroviral transduction. To validate synonymous mutant of MLL-AF4 is phenotypically similar to the MLL-mAf4, we analyzed the gene expression profiles by RNA-seq.
ORGANISM(S): Mus musculus
PROVIDER: GSE201503 | GEO | 2022/10/20
REPOSITORIES: GEO
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