Transcriptomics

Dataset Information

0

Unbiased screening identifies TGF-β signaling and Creb5 cooperatively regulate FGF18 to control pharyngeal muscle development


ABSTRACT: In the present work, we investigated the mechanism that regulates perimysial-to-myogenic communication using the development of the pharyngeal muscle LVP as a model. Using unbiased single-cell RNAseq (scRNAseq) data analysis combined with mouse genetic approaches, we identified TGF-β signaling as the predominant signaling activity that enables the perimysial cells to interact with the adjacent myogenic cells during late pharyngeal muscle development. Furthermore, we identified that perimysial-specific regulator Creb5 interacts specifically with TGF-β signaling to co-activate the expression of specific perimysial-to-myogenic signals such as Fgf18 to regulate pharyngeal myogenesis. Taken together, our findings reveal that TGF-b signaling and perimysial-specific regulators may cooperatively define perimysial-to-myogenic signals in regulating pharyngeal myogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE203035 | GEO | 2022/12/14

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA838213 | ENA
2017-05-15 | E-GEOD-29547 | biostudies-arrayexpress
2017-05-15 | E-GEOD-29546 | biostudies-arrayexpress
2011-07-05 | E-GEOD-22283 | biostudies-arrayexpress
2017-05-15 | GSE29547 | GEO
2022-11-07 | GSE181883 | GEO
2017-05-15 | GSE29546 | GEO
2011-07-06 | GSE22283 | GEO
2012-02-03 | E-GEOD-35357 | biostudies-arrayexpress
2012-02-03 | GSE35357 | GEO